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M9490699.TXT
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1994-09-24
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Document 0699
DOCN M9490699
TI Double-blind, randomized clinical trial on the effect of interferon-beta
in the treatment of condylomata acuminata.
DT 9411
AU Olmos L; Vilata J; Rodriguez Pichardo A; Lloret A; Ojeda A; Calderon MD;
Department of Dermatology, Hospital Clinico Universitario San; Carlos,
Madrid, Spain.
SO Int J STD AIDS. 1994 May-Jun;5(3):182-5. Unique Identifier : AIDSLINE
MED/94339220
AB A randomized, double-blind, placebo-controlled trial was conducted to
assess interferon-beta efficacy and safety in the treatment of
anogenital condylomatous lesions. One hundred patients received a daily
intramuscular injection of either interferon-beta (IFN-beta) (2 MIU/day)
or placebo for 10 days. Of 94 evaluable patients, the complete response
rate observed 8 weeks after treatment was significantly higher in the
group receiving IFN-beta, as compared to the placebo-treated group (51%
vs 28.9%, P < 0.05). After one year, 24 patients (100%) out of 24
complete responders to IFN-beta who attended for follow-up remained free
of lesions. Twelve of 13 patients with complete response to placebo
(92.3%) remained free of lesions after one year. Side effects were mild
and no significant analytical changes were observed. In conclusion,
interferon-beta is an effective and safe treatment for long-term
eradication of anogenital condylomatous lesions.
DE Adult Condylomata Acuminata/*THERAPY Double-Blind Method Female
Follow-Up Studies Human Injections, Intramuscular
Interferon-beta/ADMINISTRATION & DOSAGE/ADVERSE EFFECTS/ *THERAPEUTIC
USE Male Middle Age Spain Support, Non-U.S. Gov't CLINICAL TRIAL
CLINICAL TRIAL, PHASE III JOURNAL ARTICLE MULTICENTER STUDY
RANDOMIZED CONTROLLED TRIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).